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KMID : 0352720070310040217
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Journal of Ginseng Research
2007 Volume.31 No. 4 p.217 ~ p.221
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Anxiolytic-like Effects of Saponin and Polysaccharide Fractions Extracted from White and Red Ginsengs in the Elevated Plus-Maze Model
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Kim Tae-Woo
Choi Hyuck-Jai
Kim Nam-Jae
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Abstract
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Ginseng has been widely used for the management of anxiety and emotional instability, but there is little experimental evidence supporting these clinical applications. The anxiolytic-like effect of ginseng saponin and polysaccharide fractions of white (WG) and red ginsengs (RG) was investigated using the elevated plus-maze test. The saponin (SF) and polysaccharide (PF) fractions were orally administered to male ICR mice for 3 days and behavioral test for the anxiolytic activity were performed. SF significantly increased the time-spent open arms and number into the in the open arm entries. However, PF weakly increased the time-spent in the open arms, but did not increase number into the open arm entries. The WG showed more potent anxiolytic-like effect than that of RG.. The anxiolytic-like activities were antagonized by flumazenil, but not by esmolol. These findings suggest the saponin fractions of WG and RG promote the anxiolytic-like activity by antagonizing GABA/benzodiazepine receptors in mice.
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KEYWORD
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Panax ginseng, anxiety, saponin, polysaccharide, GABA receptor
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